The XRN1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to XRN1. This antibody recognizes Human, and Mouse antigen. The XRN1 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
Subunit Structure: Found in a mRNP complex with UPF1, UPF2, UPF3B and XRN1 (PubMed:14527413). Associates with alpha and beta tubulins (By similarity). Interacts with DIS3L2 (PubMed:23756462). Interacts with ZC3HAV1 in an RNA-dependent manner (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).
Similarity: Belongs to the 5'-3' exonuclease family